Angiotensin II Receptor Blockers or ARBs drugs are common medicines given to people with hypertension. Here’s what you need to know about its mechanism of action, administration, and side-effects.
Medically reviewed by John Paul Abrina, MD · Oncology · Davao Doctors Hospital
Angiotensin II Receptor Blockers or ARBs drugs are common medicines given to people with hypertension. Here’s what you need to know about its mechanism of action, administration, and side-effects.
Before we talk about their mechanism of action, administration, and side-effects, let’s first enumerate the examples of angiotensin II receptor blockers. They include the “sartan” medicines, like:
While angiotensin II receptor blockers are common medicines for hypertension, please note that doctors also prescribe them for other conditions, such as heart failure and chronic kidney disease. Patients may also receive these medicines after experiencing a heart attack.
But, how do the “sartan” drugs work for hypertension? What’s their mechanism of action?
ARBs drugs work by blocking the receptors where the hormone angiotensin II acts on. Angiotensin II is largely responsible for the constriction of blood vessels and salt and water retention, both of which contribute to increased blood pressure.
By blocking the receptor, ARBs drugs inhibit the effects of angiotensin II, helping treat hypertension.
Angiotensin-converting enzyme (ACE) inhibitors produce the same effect as the “sartan” drugs. However, their mechanism of action is different.
Where angiotensin II receptor blockers inhibit the action of the hormone, ACE inhibitors, on the other hand, prevent certain enzymes from producing angiotensin II.
The administration of angiotensin II receptor blockers depends on the specific medicine your doctor gives you.
“Sartan” medicines come in various dosage forms; the doctor may give you the initial dose once daily or increase it based on your condition or response.
Note that all angiotensin II receptor blockers have a maximum daily dose. For instance, the maximum daily dose of losartan is 100 mg; valsartan, on the other hand, has a maximum daily dose of 320 mg.
Other general rules in administration include:
Finally, go to your doctor’s appointment for a follow-up check-up. Don’t forget to bring all the necessary laboratory test results, the record of your blood pressure readings, and the record of side effects, if there were any. This is so the doctor can determine whether the medicine is working well.
If you’re taking any of the ARBs drugs, you may experience the following side-effects:
Also, please keep in mind that some angiotensin II receptor blockers may have side effects that other ARBs drugs do not list. Case in point: olmesartan may lead to digestive symptoms, like diarrhea.
Before prescribing you any angiotensin II receptor blocker, the doctor will talk to you about your other medications.
This is because it’s common for hypertensive patients to have more than just one type of medicine (especially in the case of resistant hypertension). If the doctor discontinues or changes some of your medications, it’s probably because of the possibility of drug interactions.
For instance, taking potassium-sparing water pills or painkillers while you’re under angiotensin II receptor blockers further increases the risk of hyperkalemia (high potassium levels in the blood).
Likewise, the doctor might ask you to strictly limit your alcohol intake and avoid salt substitutes that contain potassium.
Learn more about Hypertension here.
Disclaimer
Hello Health Group does not provide medical advice, diagnosis or treatment.
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