The plague can be transmitted via direct contact with infected fleas, skin, or saliva droplets. This had such a devastating effect that around 5,000 people were killed each day. This was around a quarter of the Eastern Mediterranean populace.
During this time, plague doctors who donned bird beak-shaped masks tried their best to figure out how to treat the pandemic. But to no avail. They used multiple methods to ward off the disease such as a vinegar-water solution, bloodletting, witchcraft and even charms.
The Black Death (1346-1353)
One of the most well-known deadliest diseases in history, the black death killed over 75 to 200 million people across Europe, Africa, and Asia. A possible explanation for its widespread infection was the merchant ships that unintentionally spread infected pests, which thrived in environments such as the ports near human settlements and communities.
Much like the Justinian plague, there was no cure available at that time.
People speculate that the bubonic plague ended because of intense quarantine protocols enforced to cease any further growth of the disease. Another plausible explanation would be that the pathogen simply ran out of victims, which led to its eventual extinction.
Third Cholera Pandemic (1852-1860)
Known as the deadliest cholera pandemic, the third cholera pandemic spread through Asia, Europe, North America, and Africa which ended up killing more than a million people, making it one of the deadliest diseases in history. In 1854, John Snow, a physician from Britain, found out that contaminated water was indeed the main means of transmission for cholera.
The cholera pandemic fluctuated throughout history, making it hard to overcome. The pandemic would die out only to reemerge once more after a few years at a time. Fortunately, the first cholera vaccine created in 1885 prevented drastic increases in cholera cases.
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